Rare variant burden analysis within enhancers identifies CAV1 as an ALS risk gene

(Cell Reports 33, 108456-1–108456-8.e1–e5; December 1, 2020) In the originally published version of this article, Eran Elhaik was incorrectly spelled in author list. The corrected list appears here and with article online. authors regret error. Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk GeneCooper-Knock et al.Cell ReportsDecember 01, 2020In BriefCooper-Knock al. identify amyotrophic lateral sclerosis (ALS) risk variants non-coding regulatory DNA linked to a known gene, TBK1, but also CAV2. Disease-associated reduce CAV1/CAV2 expression disrupt membrane lipid rafts consequences for neurotrophic signaling. coding sequence contains ALS-associated mutations. Full-Text PDF Open Access